Fig. 11. ROCK controls the cytoskeletal dynamics and YAP/TAZ localization and activation. (A) Activation of ROCK isoforms by GTP-bound RhoA downstream of G protein-coupled receptors, such as LPA1 and PAR1. (B) Activated ROCKs phosphorylate MLC phosphatase, inhibiting its ability to dephosphorylate (and inactivate) MLC. Persistently phosphorylated active MLC is then able to induce stress fiber and focal adhesion formation, and cell contraction that leads to YAP/TAZ activation and nuclear localization [109].